Fig. 2
From: Metabolome profiling across liver lobes and metabolic shifts of the MASLD mice
The HFD and HFHC diets trigger time-dependent changes in the hepatic lipidome and metabolome. (A) PLS-DA analysis of lipids and metablites in L1, L2, L3, L4, L5 lobes (R2, Q2>0.8). (B) Number of DEMs after various feeding periods of HFD and HFHC in 5 liver lobes. (C) Heat map of the differentially expressed metabolites (detected by lipidome) among 5 liver lobes in mice fed HFD and HFHC for 8 weeks or 16 weeks. One-way ANOVA was used to identify differences among different interventions. Post-hoc analysis was conducted using the LSD test to perform sufficient comparisons. *indicates comparisons between dietary interventions and the corresponding time-point LFD (8HFHC/8HFD vs. 8LFD, 16HFHC/16HFD vs. 16LFD). # indicates comparisons between different time points under the same dietary intervention (16LFD vs. 8LFD, 16LFD vs. 8LFD, 16HFHC vs. 8HFHC). ^indicates comparisons between HFHC and HFD at same feeding time (8HFHC vs. 8HFD, 16HFHC vs. 16HFD). */#/^ P < 0.05, **/## /^^P < 0.01, ***/###/^^^ P < 0.001