Fig. 5

Manhattan plot displays gene-level interaction p-values as a function of chromosomal position for the upstream (red) and downstream (green) pathways. The y-axis shows -log(p) for gene-level enrichment tests of interaction effects from MAGMA, while the x-axis indicates the chromosomal position of the 5’ gene boundary. The dotted line denotes a Bonferroni significance threshold accounting for 18,249 genes tested. Colored points correspond to genes reaching FDR q < 0.05