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Fig. 2 | Genes & Nutrition

Fig. 2

From: Decomposed interaction testing improves detection of genetic modifiers of the relationship of dietary omega-3 fatty acid intake and its plasma biomarkers with hsCRP in the UK Biobank

Fig. 2

Relationships and mediation between dietary N3FA, plasma N3FA, and hsCRP. a-c Curves show the relationship between dN3FA and pN3FA (a), pN3FA and non-transformed hsCRP (b), and dN3FA and non-transformed hsCRP (c). Curves were estimated using a restricted cubic spline with 3 knots. X-axes correspond to estimated dN3FA (units of % total blood fatty acids due to the derivation of this dietary intake proxy; see Methods) or pN3FA (same units). Y-axes correspond to pN3FA or hsCRP (mg/L). d Estimates and 95% CIs for the total, mediated (indirect; ACME), and direct effects from mediation analysis are shown for the pathway in which pN3FA mediates the dN3FA-hsCRP relationship. e ACME (mediated effect) estimates are shown using either total % N3FA (i.e., total pN3FA) or subsets of this quantity (DHA and non-DHA; see Methods) as the mediating quantity

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Genes & Nutrition

ISSN: 1865-3499

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