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Table 1 Participants characteristics at baseline by intervention group and TCF7L2 genotype

From: Changes in triglyceride-rich lipoprotein particle profiles in response to one-week on a low fat or Mediterranean diet by TCF7L2 rs7903146 genotype: a randomized crossover dietary intervention trial

 

LF2MetD

MetD2LF

Global P3

CC genotype

TT genotype

P2

CC genotype

TT genotype

P2

n

12

8

 

9

6

  

Sex, male

8 (67%)

6 (75%)

> 0.99

4 (44%)

2 (33%)

> 0.99

0.328

Age, years

49.9 ± 17.9

46.5 ± 19.9

0.702

47.2 ± 16.9

37.7 ± 22

0.391

0.636

BMI, kg/m2

30.6 ± 2

29 ± 2.3

0.139

30.6 ± 1.9

31.1 ± 2

0.653

0.228

Cholesterol, mmol/L4

       

Total cholesterol

4.69 ± 0.83

4.2 ± 0.73

0.179

4.9 ± 1.02

5.24 ± 0.96

0.524

0.175

VLDL cholesterol

0.63 ± 0.18

0.52 ± 0.16

0.189

0.75 ± 0.31

0.8 ± 0.3

0.735

0.109

LDL cholesterol

2.9 ± 0.74

2.42 ± 0.53

0.105

3.02 ± 0.74

3.34 ± 0.78

0.439

0.119

HDL cholesterol

1.37 ± 0.21

1.36 ± 0.31

0.905

1.35 ± 0.22

1.35 ± 0.17

0.985

0.996

Triglyceride, mmol/L

0.85 ± 0.24

0.73 ± 0.33

0.387

1.27 ± 0.78

1.09 ± 0.44

0.579

0.113

TRL triglyceride, mmol/L

       

Total TRL

0.61 ± 0.17

0.52 ± 0.26

0.397

0.89 ± 0.49

0.78 ± 0.33

0.598

0.091

XL VLDL

0.07 ± 0.04

0.05 ± 0.05

0.397

0.12 ± 0.1

0.09 ± 0.06

0.498

0.108

L VLDL

0.12 ± 0.05

0.1 ± 0.07

0.488

0.19 ± 0.13

0.16 ± 0.08

0.589

0.104

M VLDL

0.2 ± 0.06

0.17 ± 0.09

0.433

0.29 ± 0.15

0.27 ± 0.11

0.683

0.084

S VLDL

0.1 ± 0.02

0.09 ± 0.03

0.422

0.15 ± 0.07

0.13 ± 0.05

0.537

0.077

XS VLDL

0.05 ± 0.01

0.04 ± 0.01

0.249

0.06 ± 0.02

0.05 ± 0.02

0.655

0.235

IDL

0.07 ± 0.01

0.07 ± 0.01

0.212

0.08 ± 0.03

0.08 ± 0.02

0.866

0.426

  1. 1Values are mean ± SD or n (%), unless otherwise specified. BMI, body mass index; IDL, Intermediate density lipoprotein; LF2MetD, Low fat to Mediterranean diet order; MetD2LF, Mediterranean to Low fat diet order; TRL, triglyceride-rich lipoprotein; VLDL, very low density lipoprotein
  2. 2P for difference between genotype for each diet group from T-test or Fischer’s exact test for continuous or categorical variables, respectively
  3. 3P for global difference across 4 groups (by diet group and genotype) from two-way ANOVA
  4. 4Data from ”Clinical LDL Cholesterol’ variable in Nightingale platform; provides concentrations consistent with routine clinical chemistry and the Friedewald equation
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Genes & Nutrition

ISSN: 1865-3499

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