Fig. 7
From: Genistein inhibited endocytosis and fibrogenesis in keloid via CTGF signaling pathways
A schematic representation of the molecular mechanisms of genistein-inhibited endocytosis and fibrogenesis in keloid via CTGF signaling pathways Genistein promoted cell cycle arrest at the G2/M phase and inhibited the expression of COL1A1, FN, and CTGF mRNA and protein expressions. Genistein enhanced endocytosis in keloids and blocked the stimulation of growth factors (PDGF, FGF). This process may depend on the regulation of CTGF. Genistein may attenuate the activity of keloid fibroblasts and reduce keloid formation