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Table 2 DEGs involved in OA pathogenesis comparing CGH vs. CTR groups

From: Effects of the oral administration of glycosaminoglycans with or without native type II collagen on the articular cartilage transcriptome in an osteoarthritic-induced rabbit model

Gene Symbol

Associated Protein

p-value

Fold-Change

UP/

DOWN

Fgf10

Fibroblast growth factor 10

0.004

-1.300

DOWN

Adamts9

ADAM metallopeptidase with thrombospondin type 1 motif, 9

0.002

-1.163

DOWN

Med12l

Mediator complex subunit 12-like

0.004

-1.158

DOWN

Chsy3

Chondroitin sulfate synthase 3

0.002

1.195

UP

Znf410

Zinc finger protein 410

0.005

1.315

UP

Socs2

Suppressor of cytokine signalling 2

0.003

1.662

UP

Il16

Interleukin 16

0.0002

1.772

UP

Col2A1

Collagen, type II, alpha 1

0.004

2.196

UP

Aldh6A11

Aldehyde dehydrogenase 6 family, member A1

0.002

2.479

UP

Acan

Aggrecan

0.003

2.495

UP

Fn1

Fibronectin 1

0.004

2.513

UP

S100A1

S100 calcium binding protein A1

0.002

2.864

UP

S100A6

S100 calcium binding protein A6

0.0001

3.518

UP

  1. OA pathogenesis-related DEGs (p < 0.005) in CGH rabbits compared to CTR rabbits (Student’s t test), sorted by Fold-Change