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Table 6 Evidence on specific functional relationships between vitamin metabolism pathways and long noncoding RNAs (lncRNAs)

From: Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

Compound

LncRNA(s) studied in the project

System: Patients / cell line(s) / animal model

Highlighted lncRNA(s)/pathway(s)/target(s)/ partners/ interactions

Disease context/ implication for human disease

Main result(s)

Ref

Vitamin digestion and absorption (soluble and non-soluble)

To identify differentially expressed lncRNAs and mRNAs, 375 gastric adenocarcinoma and 32 adjacent non-tumor tissues were selected from TCGA

Bioinformatics analysis of mRNA and lncRNA expression profiles of 375 gastric adenocarcinoma and 32 adjacent non-tumor tissues

[AC115619.1-APOA4 /APOB]

[AP006216.2-APOA1/APOA4]

HOTAIR

C20orf166-AS1, PGM5-AS1,

HOXC-AS3,

HOXC-AS2 AC012531.1

Gastric Cancer (GAC)

• HOXC-AS3 cis-regulated the homeobox transcription factor genes HOXC8, HOXC9, HOXC10, HOXC11, HOXC12 and HOXC13

• Six lncRNAs (HOTAIR, C20orf166-AS1, PGM5-AS1, HOXC-AS3, HOXC-AS2, and AC012531.1) showed excellent diagnostic value as biomarkers for GAC

[108]

Vitamin digestion and absorption

RNA sequencing of Hu sheep liver (with and without heat stress) inferred 520 DE mRNAs and 22 DE lncRNAs

Liver tissue of Hu Sheep

DE mRNAs showed enrichment in particular pathways including vitamin digestion and absorption

Animal health (productivity & reproductive efficiency)

Lnc_001782, because of its potential cis-regulatory effect, may positively regulate APOA4 and APOA5, two genes that are its genomic neighbors

[109]