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Table 5 Evidence of functional relationships between the Vitamin C group and long noncoding RNAs (lncRNAs)

From: Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs

Vitamin

LncRNA(s) studied in the project

System: Patients / cell line(s) / animal model

Highlighted lncRNA(s)/pathway(s)/target(s)/ partners/ interactions

Disease context/ implication for human disease

Main result(s)

Ref

Vitamin C

Differentially expressed mRNAs (1232) and lncRNAs (937) after treatment with ascorbic acid

Swine testicular cell line

MAPK, AMPK, PI3K-Akt and mTOR and pathways regulating cell proliferation and cell cycle

Reproduction of male animals

transcriptomic analysis demonstrated AA-induced differentially expressed mRNAs and lncRNAs enriched in MAPK, AMPK, PI3K-Akt and mTOR and pathways

[104]

MALAT1

Human CRC cell lines: LS174T, HT-29, and SW480

Athymic nude mice (Balb/c, nu/nu)

_

Colorectal Cancer

Vitamin C could suppress proliferation, induce apoptosis and arrest cell cycle. More killing effects were observed in cells with high MALAT1 expression

[105]

RNA sequencing of donner cells before and after vitamin C treatment/ differentially expressed mRNAs and lncRNAs

Oocytes and donor fibroblasts of bovine origin

_

improve cloned bovine embryo formation by somatic cell nuclear transfer from fibroblast donor cells

Vitamin C improved colony formation by restoring mRNA and lncRNA expression signature

[106]

X-inactive specific transcript (Xist)

Mouse embryonic fibroblasts (MEFs)

_

Reprogramming of female somatic cells into induced pluripotent stem cells (iPSCs)

Vitamin C has a key role in keeping Xist repressed, reactivating the X chromosome during the pre‐iPSC to iPSC transition

[107]

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Genes & Nutrition

ISSN: 1865-3499

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