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Table 2 Base model of associations between serum Mg2+ concentrations and the lead regional genome-wide significant SNPs.

From: Genome-wide association study of serum magnesium in type 2 diabetes

SNP

chr

Location

Allele frequencya

Function

Codedb

Closest gene

% Variance explained

Beta (mmol/L)

SE

P

rs7894336

10

8026609

0.53

Intronic

C>T

TAF3

0.54

− 0.011

0.002

2.9E−9

rs11264341

1

155151493

0.47

Intronic

C>T

TRIM46

0.44

0.010

0.002

2.9E−7

rs10019833

4

77357592

0.37

Intronic

T>C

SHROOM3

0.41

0.010

0.002

4.0E−7

rs2270860

6

43270151

0.31

Synonymous

C>T

SLC22A7

0.28

− 0.010

0.002

1.0E−6

  1. Base model is adjusted for age, sex, and PC 1-3
  2. chr = chromosome, Mg2+ = magnesium ion, PC = principal component, SE = standard error, SNP = single nucleotide polymorphism
  3. aAllele frequency is for European populations, according to the gnomAD database v3.1.2. [27]
  4. bCoded alleles are inversely associated with serum Mg2+
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Genes & Nutrition

ISSN: 1865-3499

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