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Fig. 7 | Genes & Nutrition

Fig. 7

From: Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity

Fig. 7

Cell type responses in mitochondrial mass. Decreased SHMT2 leads to increased mitochondrial mass. Citrate synthase activity in A HAP1 cells and ΔSHMT2 cells and B Shmt2+/+ and Shmt2+/− MEF cells. Citrate synthase activity was normalized to total protein. Two-way ANOVA with Tukey’s post hoc analysis was used to determine media by genotype interaction and main effects of media and genotype with a statistical significance at p < 0.05. Levels not connected by the same letter are significantly different. Data represent means ± SD values, n = 4 per group with 2 embryo cells lines represented in each group. CS, citrate synthase

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