Effect of flaxseed oil supplementation on the erythrocyte membrane fatty acid composition and endocannabinoid system modulation in patients with coronary artery disease: a double-blind randomized controlled trial

Table 2 Effect of flaxseed oil supplementation on fatty acids status of erythrocytes

Variable	Flaxseed oil (n = 21)	Placebo (n = 19)	MD (95% CI), P value
LA (%)
Before	14.53 (6.22)	15.59 (8.48)	1.32 (− 4.26 to 6.90), 0.632^a
After	9.68 (3.25)	12.10 (3.94)	2.89 (0.07 to 5.72), 0.045^b
MD (95% CI), P value^c	− 4.84 (− 9.16 to − 0.53), 0.031	− 3.49 (− 7.18 to 0.19), 0.062
AA (%)
Before	13.59 (5.64)	11.59 (6.87)	− 1.21 (− 6.07 to 3.65), 0.613^a
After	9.56 (1.40)	8.75 (1.56)	− 1.06 (− 2.47 to 0.36), 0.135^b
MD (95% CI), P value^c	− 4.03 (− 7.46 to − 0.60), 0.026	− 2.84 (− 6.76 to 1.07), 0.143
ALA (%)
Before	0.20 (0.12)	0.21 (0.11)	0.01 (− 0.07 to 0.10), 0.679^a
After	0.56 (0.24)	0.22 (0.10)	− 0.35 (− 0.51 to − 0.20), < 0.001^b
MD (95% CI), P value^c	0.37 (0.23 to 0.51), < 0.001	0.004 (− 0.08 to 0.09), 0.925
EPA (%)
Before	1.15 (0.60)	1.08 (0.87)	− 0.28 (− 0.84 to 0.27), 0.301^a
After	1.06 (0.72)	0.87 (0.50)	− 0.29 (− 0.96 to 0.37), 0.364^b
MD (95% CI), P value^c	− 0.09 (− 0.51 to 0.32), 0.612	− 0.21 (− 0.65 to 0.22), 0.305
DHA (%)
Before	1.43 (0.87)	1.24 (0.76)	− 0.20 (− 0.83 to 0.43), 0.520^a
After	1.36 (0.44)	1.29 (0.46)	− 0.08 (− 0.52 to 0.36), 0.704^b
MD (95% CI), P value^c	− 0.07 (− 0.80 to 0.65), 0.822	0.05 (− 0.35 to 0.45), 0.796

Values are expressed as mean (SD)
LA linoleic acid, AA arachidonic acid, ALA α-linolenic acid, EPA eicosapentaenoic acid, DHA docosahexaenoic acid, MD mean difference
^aIndependent samples t-test
^bAdjusted for baseline values, weight differences, and energy and fat intake changes using the analysis of covariance (ANCOVA) test
^cPaired-samples t-test

ISSN: 1865-3499