From: Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice
Scientific validity assessment criteria | |
---|---|
Study quality rating (A, B, C, D): * Interventional or observational design * Prospective and retrospective approach * Randomised, placebo controlled and blinded * Study power (high subject number with ‘effect’ allele) * Effect magnitude * P values, false discover rate (FDR) and multiple testing * Replication study in different populations and meta-analysis Type of gene × diet Interaction: * Direct phenotype * Intermediate phenotype * Indirect phenotype Nature of the genetic variant * Causal * In LD with functional variant * Associated but unknown function Biological plausibility * Rated as high/medium/low/unknown Scientific validity score for gene × diet interaction * Convincing * Probable * Possible * Not demonstrated |